广西师范大学学报（哲学社会科学版） ›› 2021, Vol. 39 ›› Issue (2): 139-143.doi: 10.16088/j.issn.1001-6600.2020060902

• CCIR2020 • 上一篇    下一篇

广豆根内生真菌GDG-178代谢产物研究

李本超1,2, 梁艳1,2, 覃小芽1,2, 莫土香1,2, 徐照隆1,2, 李俊1,2, 杨瑞云1,2*   

  1. 1.广西师范大学 化学与药学学院,广西 桂林541004;
    2.省部共建药用资源化学与药物分子工程国家重点实验室/广西民族药省部共建协同创新中心广西师范大学,广西 桂林541004
  • 收稿日期:2020-06-09 修回日期:2020-09-10 出版日期:2021-03-25 发布日期:2021-04-15
  • 通讯作者: 杨瑞云(1978—),女,广西桂林人,广西师范大学研究员,博士。E-mail:yang_rui_yun@163.com
  • 基金资助:
    国家自然科学基金(21762007);广西自然科学基金(2018GXNSFAA281169);药用资源化学与药物分子工程国家重点实验室资助项目(CMEMR2018-C29)

Secondary Metabolites of Endophytic Fungus GDG-178 from Sophora tonkinensis

LI Benchao1,2, LIANG Yan1,2, QIN Xiaoya1,2, MO Tuxiang1,2, XU Zhaolong1,2, LI Jun1,2, YANG Ruiyun1,2*   

  1. 1. College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin Guangxi 541004, China;
    2. State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine Guangxi Normal University, Guilin Guangxi 541004, China
  • Received:2020-06-09 Revised:2020-09-10 Online:2021-03-25 Published:2021-04-15

摘要： 采用硅胶柱层析、 ODS柱层析、 Sephadex LH-20以及半制备HPLC等方法,从广豆根内生真菌GDG-178(Fusarium equiseti)代谢产物中分离得到10个化合物,通过波谱分析,鉴定化合物的结构分别为:白僵菌素 (1)、fusaproliferin (2)、11-epiterpestacin (3)、吲哚-3-乙酸 (4)、indole-3-methylethanoate (5)、4-methyl-5,6-dihydro-2H-pyran-2-one (6)、柄曲霉素 (7)、2′-hydroxydecanylpentadec-5,8,10,12-tetraneoate (8)、19-norergosta-5,7,9,22-tetraene-3β-ol (9)、对羟基苯甲醛 (10)。其中,化合物7~10为首次从镰刀菌属Fusarium sp.中分离得到,化合物5和6为首次从木贼镰刀菌Fusarium equiseti中分离得到。

关键词: 广豆根, 内生真菌, 镰刀菌属, 木贼镰刀菌, 代谢产物

Abstract: Ten compounds were isolated from the metabolites of endophytic fungus GDG-178(Fusarium equiseti)by using silica gel column chromatography, ODS chromatography, SephadexLH-20 and semi-prepared HPLC. The structures of these compounds, beauvericin (1), fusaproliferin (2), 11-epiterpestacin (3), 3-indoleacetic acid (4), indole-3-methylethanoate (5), 4-methyl-5,6-dihydro-2H-pyran-2-one (6), sterigmatocystin (7), 2′-hydroxydecanylpentadec-5,8,10,12-tetraneoate (8), 19-norergosta-5,7,9,22-tetraene-3β-ol (9) and p-hydroxy benzaldehyde (10), were identified by spectral analysis. Compounds 7-10 were obtained from Fusarium sp. for the first time. And compounds 5 and 6 were firstly obtained from Fusarium equiseti.

Key words: Sophora tonkinensis, endophytic fungi, Fusarium sp., Fusarium equiseti, metabolites

中图分类号: 

  • O629.9
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